Автор:
Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K.
Год:
2012
Файл:
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Публикация: Auto Immun Highlights. 2012 Oct 30;3(3):119-25.
Ключевые слова: Autoantibody, Autoimmune hepatitis, Autoimmunity, Liver disease, Primary biliary cirrhosis
Аннотация
Asialoglycoprotein receptor (ASGPR) autoantibodies have been considered specific markers of autoimmune hepatitis (AIH). The exact mechanisms responsible for the development of these autoantibodies and leading to autoimmunity to this peculiar liver receptor remain elusive. Furthermore, loss of T cell tolerance to ASGPR has been demonstrated in patients with AIH, but it is poorly understood whether such liver-specific T cell responses bear a pathogenic potential and/or participate in the precipitation of AIH. Newly developed enzyme-linked immunosorbent assays have led to the investigation of the sensitivity and specificity of anti-ASGPR antibodies for AIH. The present review provides an overview of the diagnostic and clinical relevance of anti-ASGPR antibodies. A thorough investigation of the autoreactivity against ASGPR may assist efforts to understand liver autoimmunity in susceptible individuals.
Процитировать:
Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K. Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity. Auto Immun Highlights. 2012 Oct 30;3(3):119-25. doi: 10.1007/s13317-012-0041-4. PMID: 26000135; PMCID: PMC4389076.