Автор:
Novikova V.P., Revnova M.O., Shapovalova N.S., Azanchevskaya S.V., Kalinina E.Yu., Lapin S.V., Guseva V.I.
Год:
2016
Публикация: 8th Excellence in Pediatrics Conference - 2016 Book of Abstracts. Cogent Medicine, Volume 3, 2016 - Issue 1.
Ключевые слова: Atrophic Gastritis, Celiac Disease
Аннотация
Purpose: To determine the prevalence of atrophic gastritis in children with celiac disease. To determine the frequency of Helicobacter pylori (H. pylori) and antiparietal cell antibodies as a possible causes of atrophic gastritis.
Materials and Methods: 88 children of both sexes at the age of 3 to 17 years were examined. The study involved 54 children with different clinical forms of celiac disease (CD). The diagnosis was confirmed according to ESPGHAN criteria: was biopsy-prove, was based on clinical manifestation, positive serological and genetic data. 34 children with chronic gastritis and excluded celiac disease were a control group. All patients underwent a same examination: histological examination of gastric biopsies, histological verification of H. pylori infection and biopsy urease test, identification of
antiparietal cell antibodies by enzyme immunoassay (ELISA). The biopsies were evaluated by a single pathologist who was blinded to all clinical data.
Results: In the group of patients with celiac disease chronic isolated corpus gastritis was diagnosed more frequently than in the control (61.1% and 5.9% p < 0.01) biopsies of the gastric corpus mucosa in patients with CD was characterized by neutrophilic infiltration in comparison with control (53,7% and 26.5% p < 0.05). The difference in antrum samples was not received (7,4% and 14.7 p>0.05). Fibrosis in the lamina propria of the gastric corpus was more prevalent in CD group (53.7% and 26.5% p < 0.05). For gastric antrum the difference wasn’t obtained (68.5% and 55.9% p>0.05). Among patients with CD we found gastric corpus atrophy in 11 cases and in the antrum in 8 cases. In control group corpus atrophy was in 4 cases and antrum atrophy was in 5 cases. Thus, the statistical difference in groups hadn’t been received (35,2% and 26.5% p>0.05) In a majority of patients in both groups H. pylori was diagnosed (53.7% in the CD group and 55.9% in the control group p>0.05). Nevertheless antiparietal cell antibodies in the control group were not revealed. While we detected
them in the CD group in 4 cases (0% and 7.4% p < 0.01).
Conclusion: Atrophic gastritis was common for both groups. H. pylori rate was statistically equal. Nevertheless antiparietal cell antibodies were observed in CD group only, with the prevalence 7.4% or 1:13.5.
Процитировать:
Novikova V.P., Revnova M.O., Shapovalova N.S., Azanchevskaya S.V., Kalinina E.Yu., Lapin S.V., Guseva V.I. Atrophic gastritis in children with celiac desease. 8th Excellence in Pediatrics Conference - 2016 Book of Abstracts. Cogent Medicine, Volume 3, 2016 - Issue 1.