
Автор:
Gaydukova I.Z., Rebrov A., Maslyanskiy A., Lapin S., Vasilenko E., Mazurov V.
Год:
2018
Файл:
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Публикация: Annals of the Rheumatic Diseases 77(Suppl 2):348.1-348. June 2018
Аннотация
Background.
The problem of axial spondyloarthritis’ (axSpA) differential diagnostics is not solved, especially in the early stages of the axSpA. Therefore, new diagnostic markers for axSpA are needed.
Objectives
of the study were to evaluate the prevalence, sensitivity and specificity of anti-CD74 autoantibodies (anti-CD74-AB) in HLA-B27 associated axSpA in comparison with HLA-B27 associated axial Psoriatic arthritis (axPsA) and with healthy controls.
Methods.
Anti-CD74-AB (quantitative ELISA) were measured in serum of 114 HLA-B27-positive patients with axSpA, and in 26 age- and sex – matched HLA-B27 positive patients with axPsA, and in 37 healthy controls without HLA-B27. 68 axSpA patients had ankylosing spondylitis (AS) according mNew-York criteria (1984), 46 axSpA persons had non-radiographic axSpA (nr-axSpA) due to ASAS criteria for axSpA (2009). AxPsA patients had psoriatic arthritis with axial involvement and fulfilled both CASPAR (2006) and ASAS axSpA criteria (2009). Disease activity in axSpA and axPsA patients was measured according ASAS recommendations.
Results.
Patients with AS, nr-axSpA and axPsA were comparable in SpA activity: differences in BASDAI, ASDAS indices and C-reactive protein levels were not significant, p≥0.05 for all. Nr-axSpA patients had shorter disease duration as compared with AS and axPsA patients (p<0.001). The concentration of anti-CD74-AB in patients with axSpA was 3.5±3.0 U/ml (3.1±3.0 U/ml in AS and 3.8±2.9 U/ml in nr-axSpA patients), 2.1±1.4 U/ml in patients with axPsA (p≥0.05 compared to controls and ax-SpA)) and 1.3±1.4 U/ml in healthy controls (p<0.05 for the difference with ax-SpA, AS and nr-axSpA). Diagnostic values of anti-CD74-AB in axSpA (ROC-analyse results) are presented in table 1. Cut-off value of anti-CD74-AB>2.0 U/ml in patients with axSpA showed the diagnostic sensitivity of 64.4%, specificity of 89.2%, the positive LR of 5.9, whereas in patients with nr-axSpA at concentrations of 1.7 U/ml - sensitivity 73.1%, specificity 84% and positive LR 4.5. Conclusions. Anti-CD74-AB are strongly associated with nr-axSpA and less – axPsA. The measurement of anti-CD74-AB can be considered as candidate biomarker in the diagnostics of axSpA and in differential diagnostics between HLA-B27 positive ax-SpA and axPsA, especially in early stages of the diseases. Further studies are needed for the evaluation of anti-CD74-AB diagnostic capacity.
Процитировать:
Gaydukova, I.Z. & Rebrov, Andrey & Maslyanskiy, Alexey & Lapin, Sergey & Vasilenko, E. & Mazurov, V.. (2018). THU0258 Diagnostic value of anti-cd74 autoantibodies in axial spondyloarthritis and axial psoriatic arthritis. results of open-label, cross-sectional, controlled, multicenter progress study. Annals of the Rheumatic Diseases. 77. 348.1-348. 10.1136/annrheumdis-2018-eular.4892.