Аннотация
We studied a group of patients with longstanding rheumatoid arthritis (27 patients), a group of patients with different degree of kidney insufficiency (8 patients), and 19 healthy people. We reviewed the main contemporary methods of kidney function examination and carried out comparison between biochemical characteristics (serum creatinine level, cystatin C), calculated data of glomerular filtration rate (modification of diet in renal disease (MDRD), cystatin C, and Cockroft–Gault formulas),
results of screening for microalbuminuria, and presence or absence of amyloid deposits in subcutaneous fat tissue. As a result of our investigation, we showed that a complex of laboratory methods should be used for kidney damage diagnostics. The most informative of them are serum cystatin C and calculation of glomerular filtration rate (GFR) by MDRD and cystatin C formulas. Calculation of GFR by Cockroft–Gault formula showed to be less informative.
Процитировать:
Tishko AN, Lapin SV, Vavilova TV, Totolian AA. Early diagnostics of kidney damage in longstanding rheumatoid arthritis and amyloidosis. Amyloid. 2011 Jun;18 Suppl 1:217-8. doi: 10.3109/13506129.2011.574354081 . Erratum in: Amyloid. 2011 Jun;18 Suppl 1:218. PMID: 21838493.