Аннотация
Background: The level of acute phase indicators does not always correspond to the activity of axial spondyloarthritis (axSpA). The level of C-reactive protein (CRP) is remain normal in a third of cases of axSpA with present of active clinical symptoms. Search for new biomarker that should have increased sensitivity and specificity compared to the CRP is needed. An alternative biomarker of axSpA activity could be an immunoglobulin (Ig) A antibody to an invariant chain peptide associated with class II human leukocyte antigen (HLA) (anti-CD74).
Objectives: is to determine the level of IgA anti-CD74 in patients with axSpA and its relationship with traditional indicators of disease activity.
Methods: Totally, 137 patients with a reliable diagnosis of axial spondylitis (ASAS criteria, 2009) and 47 healthy volunteers were involved in the study. AxSpA activity indices (ASDAS, BASDAI) were calculated for all patients and IgA levels of anti-CD74, ESR and CRP were determined. The normal level according to the instructions for the laboratory kit for determining the level of IgA anti-CD74 is 12.0 U/L.
Results: Patients and volunteers characteristics are present in Table 1. As compared to controls sensitivity of IgA to anti-CD74 was 64,7%, specificity of this method was 68,1%.
Conclusion: The concentration of IgA to anti-CD74 is increased in 70.1% of pts with axSpA and associated with an increase in disease activity detected with ASDAS and BASDAI, independently from CRP. More data are needed in detection of sensitivity and specificity of IgA to CD74 in axSpA.
Процитировать:
Vasilenko, E. & Mazurov, V. & Lapin, Sergey & Kholopova, Irina & Dadalova, Anna & Gaydukova, I.. (2020). FRI0597 IMMUNOGLOBULIN A FOR CD74 AS AN ALTERNATIVE LABORATORY MARKER FOR DETERMINING THE ACTIVITY OF AXIAL SPONDYLOARTHRITIS. Annals of the Rheumatic Diseases. 79. 904.2-905. 10.1136/annrheumdis-2020-eular.4364.