Interrelations of increased axial spondyloarthritis activity and the serum concentration of immunoglobulin a to CD74 with genetic polymorphisms of interleukin 17 alleles

Автор: Vasilenko E., Korolev M., Lapin S., Kholopova I., Dadalova A., Mazurov V., Gaydukova I.

Год: 2020

Публикация: Annals of the Rheumatic Diseases. 2020. 79 (Suppl 1):1314.2-1314.

Ключевые слова: axial spondyloarthritis biomarker, IL17F polymorphism

Аннотация

Background: Genetic predisposition takes one of the main parts at pathogenesis of axial spondyloarthritis (axSpA). Currently, HLA-B27 is a single genetic marker that used in classification criteria of axSpA. However, the presence of
HLA-B27 does not affect the activity of the disease. An alternative biomarker of axSpA activity could be an immunoglobulin (Ig) A antibody to an invariant chain peptide associated with class II human leukocyte antigen (HLA) (anti-CD74).

Objectives: The goal is to determine genetic polymorphisms of IL17 alleles prevalence in patients (pts) with axSpA and their interrelations with the diseaseactivity and concentration of IgA to CD74.

Conclusion: Serum concentration of IgA to CD74 exceeded normal reference level in axSpA patients in 70.1% of cases that was associated with ASDAS and BASDAI levels. Presence of heterozygote IL-17F polymorphism in his/arg allele was associated with increasing serum concentration of IgA to CD74 and with increased disease activity (ASDAS and BASDAI). Decreasing of serum IgA to CD74 concentration, less axSpA activity (ASDAS and BASDAI) were found in patients with presence of heterozygote IL-17F polymorphism in his/his allele.

Процитировать:

Vasilenko E., Korolev M., Lapin S., Kholopova I., Dadalova A., Mazurov V., Gaydukova I. Interrelations of increased axial spondyloarthritis activity and the serum concentration of immunoglobulin a to CD74 with genetic polymorphisms of interleukin 17 alleles.Annals of the Rheumatic Diseases. 2020. 79(Suppl 1):1314.2-1314. DOI:10.1136/annrheumdis-2020-eular.4998